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Schematic outline of angiogenesis by 4 different mechanisms; (A) sprouting angiogenesis: bud initiation from capillary wall under growth factor signaling; (B) vascular cooption of nearby tissue vessels as its own source of nutrients; (C) vascular mimicry – the tumor cells adopt endothelial phenotype and form a vasculogenic-like network (D) vessel intussusception involves the splitting of pre-existing vessels into two new vascular structures.
