Table 3.

Predictors of time to occurrence of liver disease and time to abnormal ALT for entire study cohort (ICP and control patients)

Variables	Time to liver disease			Time to ALT >25 U/L			Time to ALP >140 U/L
	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
Hispanic	2.0	0.80–4.8	0.14	1.6	1.1–2.5	0.03	2.5	1.3–5.0	<0.01
AMA (≥35 yr)	1.8	0.99–3.2	0.05	1.2	0.82–1.8	0.36	0.71	0.40–1.3	0.26
GDM diagnosis in current pregnancy	1.2	0.62–2.2	0.62	1.2	0.86–1.8	0.25	0.98	0.58–1.7	0.93
Overweight or higher (BMI >25 kg/m2)	2.0	1.2–3.3	<0.01	1.2	0.94–1.6	0.14	0.77	0.55–1.1	0.12
ICP diagnosis in current pregnancy	1.5	1.03–2.9	0.05	1.9	1.5–2.6	<0.01	3.4	2.2–5.4	<0.01

ALP, alkaline phosphatase; ALT, alanine aminotransferase; AMA, advanced maternal age; BMI, body mass index; CI, confidence interval; GDM, gestational diabetes; HR, hazard ratio; ICP, intrahepatic cholestasis of pregnancy.