Table 6.
Multivariate predictors of time to occurrence of liver diseasea and time to abnormal ALT and ALP for women with ICP
| Covariates | Time to liver disease |
Time to ALT >25 U/L |
Time to ALP >140 U/L |
||||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | |
| Hispanic | 2.7 | 0.66–11.4 | 0.16 | 1.6 | 0.92–2.7 | 0.10 | 2.3 | 1.1–5.0 | 0.03 |
| AMA (≥35 yr) | 1.7 | 0.91–3.3 | 0.09 | 1.1 | 0.74–1.8 | 0.54 | 0.3 | 0.31–1.2 | 0.15 |
| GDM | 1.0 | 0.46–2.1 | 0.98 | 0.78 | 0.49–1.2 | 0.32 | 0.44 | 0.44–1.5 | 0.55 |
| Overweightor higher (BMI >25 kg/m2) | 2.1 | 1.1–3.7 | 0.02 | 1.0 | 0.75–1.3 | 0.98 | 0.54 | 0.54–1.1 | 0.15 |
| Bile acid levels >50 μmol/L | 0.61 | 0.33–1.1 | 0.12 | 0.95 | 0.69–1.3 | 0.77 | 1.3 | 0.91–1.9 | 0.15 |
| ALT >50 U/L in pregnancy | 1.3 | 0.74–2.2 | 0.38 | 1.5 | 1.1–2.1 | 0.01 | 1.4 | 0.94–2.1 | 0.10 |
ALP, alkaline phosphatase; ALT, alanine aminotransferase; AMA, advanced maternal age; BMI, body mass index; CI, confidence interval; GDM, gestational diabetes; HR, hazard ratio; ICP, intrahepatic cholestasis of pregnancy.
a
Liver disease defined by chart review and imaging findings.