TABLE 2.

Characterized of hypertension in CTCAE.

Hypertension
Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
Adult: Systolic BP 120–139 mm Hg or diastolic BP 80–89 mm Hg	Adult: Systolic BP 140–159 mm Hg or diastolic BP 90–99 mm Hg if previously WNL; change in baseline medical intervention indicated; recurrent or persistent (≥24 h); symptomatic increase by > 20 mm Hg (diastolic) or to >140/90 mm Hg; monotherapy indicated initiated	Adult: Systolic BP≥160 mm Hg or diastolic BP≥100 mm Hg; medical intervention indicated; more than one drug or more intensive therapy than previously used indicated	Adult and Pediatric: Life-threatening consequences (e.g., malignant hypertension, transient or permanent neurologic deficit, hypertensive crisis); urgent intervention indicated	Death
Pediatric: Systolic/diastolic BP > 90th percentile but< 95th percentile	Pediatric and adolescent: Recurrent or persistent (≥24 h) BP > ULN; monotherapy indicated; systolic and/or diastolic BP between the 95th percentile and 5 mmHg above the 99th percentile	Pediatric and adolescent: Systolic and/or diastolic >5 mmHg above the 99th percentile
Adolescent: BP ≥ 120/80 even if < 95th percentile	Adolescent: Systolic between 130 and 139 or diastolic between 80 and 89 even if < 95th percentile