TABLE 4.

Risk of bias of included randomized controlled trials.

Author (Year)	Random sequence generation (selection bias)	Allocation concealment (selection bias)	Blinding of participants and personnel (performance bias)	Blinding of outcome assessment (detection bias)	Incomplete outcome data (attrition bias)	Selective reporting (reporting bias)	Other bias
Baselga et al. (2012)	Low	Low	Low	Unclear	Low	Low	Low
Baselga et al. (2017)	Unclear	Unclear	Low	Low	Low	Low	Low
Cortot et al. (2020)	Low	Unclear	Unclear	Low	Low	Low	Low
Dummer et al. (2018)	Low	Low	Low	Low	Low	Low	Low
Goss et al. (2010)	Low	Low	High	Low	Low	Low	Low
Guo et al. (2020)	Unclear	Unclear	High	Unclear	Low	Low	Low
Heymach et al. (2008)	Unclear	Unclear	Low	Low	Low	Low	Low
Johnston et al. (2013)	High	Low	Unclear	Low	Low	Low	Low
Kato et al. (2012)	Low	Low	Low	Low	Low	Low	Low
Kato et al. (2012)	Low	Low	Low	Low	Low	Low	Low
Kubota et al. (2017)	Low	Low	Low	Low	Low	Low	Low
Laurie et al. (2014)	Unclear	Low	High	Low	Low	Low	Low
Liu et al. (2014)	Low	Low	Low	Low	Low	Low	Low
Liu et al. (2019)	Low	Low	Low	Low	Low	Low	Low
Lu et al. (2018)	Low	Low	Low	Low	Low	Low	Low
Mackey et al. (2015)	Low	Low	Low	Low	Low	Low	Low
Miller et al. (2005)	Low	Low	Low	Low	Low	Low	Low
Mok et al. (2011)	Unclear	Unclear	Low	Low	Low	Low	Low
Nakagawa et al. (2019)	Low	Low	Low	Low	Low	Low	Low
Rini et al. (2016)	Low	Low	Low	Low	Low	Low	Low
Rugo et al. (2011)	Low	Low	Low	Low	Low	Low	Low
Sinn et al. (2020)	Low	Low	Low	Low	Low	Low	Low
Tao et al. (2020)	Low	Low	Low	Low	Low	Low	Low
Yan et al. (2017)	Unclear	Unclear	Unclear	Low	Low	Low	Low