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. Author manuscript; available in PMC: 2021 Sep 20.
Published in final edited form as: Stem Cell Res. 2021 Aug 17;55:102506. doi: 10.1016/j.scr.2021.102506
Unique stem cell lines identifier 1. NIHTVBi015-A
2. TMOi001-A-3
3. TMOi001-A
Alternative names of stem cell lines 4. HT188 (NIHTVBi015-A)
5. 2B10 (TMOi001-A-3)
6. A18945 (TMOi001-A)
Institution 1. NIH National Heart, Lung, and Blood Institute IPSC Core
2. National Institutes of Health
3. Commercially available
Contact information of distributor Mark Cookson, cookson@mail.nih.gov
Type of cell lines iPSC
Origin Human
Cell Source 1. Fibroblasts
2. CD34 + cord blood
3. CD34 + cord blood
Clonality Clonal
Method of reprogramming 1. Sendai virus
2. Three-plasmid, seven-factor EBNA-based episomal system
3. Three-plasmid, seven-factor EBNA-based episomal system
Multiline rationale Control and disease pair
Gene modification 1. No
2. Yes
3. No
Type of modification Induced mutation
Associated disease Parkinson’s disease
Gene/locus NM:001123377.1 (PARK7): Chr1(GRCh37): g.8037720del; p.Ala111Leufs*7
Method of modification CRISPR
Name of transgene or resistance N/A
Inducible/constitutive system N/A
Date archived/stock date N/A
Cell line repository/bank N/A
Ethical approval 1. NIH Undiagnosed Diseases Program, 76-HG-0238