Unique stem cell lines identifier |
1. NIHTVBi015-A |
2. TMOi001-A-3 |
3. TMOi001-A |
Alternative names of stem cell lines |
4. HT188 (NIHTVBi015-A) |
5. 2B10 (TMOi001-A-3) |
6. A18945 (TMOi001-A) |
Institution |
1. NIH National Heart, Lung, and Blood Institute IPSC Core |
2. National Institutes of Health |
3. Commercially available |
Contact information of distributor |
Mark Cookson, cookson@mail.nih.gov
|
Type of cell lines |
iPSC |
Origin |
Human |
Cell Source |
1. Fibroblasts |
2. CD34 + cord blood |
3. CD34 + cord blood |
Clonality |
Clonal |
Method of reprogramming |
1. Sendai virus |
2. Three-plasmid, seven-factor EBNA-based episomal system |
3. Three-plasmid, seven-factor EBNA-based episomal system |
Multiline rationale |
Control and disease pair |
Gene modification |
1. No |
2. Yes |
3. No |
Type of modification |
Induced mutation |
Associated disease |
Parkinson’s disease |
Gene/locus |
NM:001123377.1 (PARK7): Chr1(GRCh37): g.8037720del; p.Ala111Leufs*7 |
Method of modification |
CRISPR |
Name of transgene or resistance |
N/A |
Inducible/constitutive system |
N/A |
Date archived/stock date |
N/A |
Cell line repository/bank |
N/A |
Ethical approval |
1. NIH Undiagnosed Diseases Program, 76-HG-0238 |