Skip to main content
. Author manuscript; available in PMC: 2022 Jan 19.
Published in final edited form as: Circ Heart Fail. 2021 Jan 19;14(1):e007300. doi: 10.1161/CIRCHEARTFAILURE.120.007300

Figure 5. CRD-733 reverses TAC-induced elevations in left ventricular (LV) end diastolic pressure and lung weight, despite sustained maximal LV pressure and TAC gradients.

Figure 5.

Figure 5.

Figure 5.

Figure 5.

Figure 5.

Figure 5.

A, Representative pressure-volume loops showing end diastolic volumes denoted by blue arrows. B, LV end diastolic pressure C, Ventricular-arterial coupling ratio and D, Maximal LV pressure obtained by invasive hemodynamics. E, Echocardiography-derived peak trans-TAC gradient after treatment. F, Normalized terminal lung weights after 21 days of TAC and 14 days of treatment. Results are expressed as mean ± SEM. Comparisons were performed using 1-way ANOVA with Tukey’s post-test; n=5-8 (B-D) and n=10-17 (E-F).