Table 1. Patients’ baseline characteristics.
| Parameter | G6PD deficient n = 18 | G6PD normal n = 57 | P value |
|---|---|---|---|
| Age years | 25 (5–56) | 24 (7–63) | 0.95 |
| Aged < 18 years* | 5 (27.8) | 10 (17.5) | 0.34 |
| Male sex | 15 (83.3) | 48 (84.2) | 0.93 |
| Weight kg | 54 (20–56) | 53 (14–88) | 0.83 |
| Days ill | 2 (0–8) | 3 (0–13) | 0.14 |
| Primaquine dose mg/kg/d | 0.74 (0.65–0.78) | 0.73 (0.53–0.98) | 0.43 |
| G6PD activity † | |||
| G6PD activity all patients | 0.85 (0.1–1.36) ‡ | 11.38 (6.67–16.78) | <0.0001 |
| G6PD activity % normal§ | 7.08 (0.83–11.33) | 94.83 (55.58–139.83) | |
| G6PD activity normal haemoglobin | 0.77 (0.1–1.2) | 11.23 (6.9–14.8) | |
| G6PD activity thalassaemia | 1.03 (0.72–1.36) | 11.57 (6.67–16.78) | |
| Haemoglobin parameters | |||
| Haemoglobin g/dL† | 12.94 (9.6–16) | 13.26 (9–16.3) | 0.48 |
| Reticulocyte count %† | 1.86 (0.6–3.8) | 1.5 (0.5–4.5) | 0.10 |
| Normal haemoglobin | 11/17 (64.7) | 31/57 (54.4) | 0.60 |
| Heterozygous HbE | 5/17 (29.4) | 20/57 (35.1) | |
| Homozygous Hb E | 0/17 | 1/57 (1.75) | |
| Alpha thalassaemia | 1/17 (5.9) | 1/57 (1.75) | |
| Beta thalassaemia | 0/17 | 4/57 (7.1) | |
| Mean corpuscular volume (MCV) fL | 87.5 (71–97) | 84 (64–98) | 0.15 |
| High MCV (> 95 fL) | 2/16 (12.5) | 2 (3.5) | 0.20 |
| Red cell distribution width (RDW) % | 12.3 (11–16.4) | 12.9 (11–15.7) | 0.83 |
| High RDW (> 14.5%) | 2/16 (12.5) | 2/54 (3.7) | 0.22 |
| Parasite data | |||
| Vivax parasitaemia/μL | 6,420 (159–9,326) | 8,300 (220–59,542) | 0.13 |
* Proportional data are shown as N (%)
† mean (range), other continuous data are median (range)
‡ includes 2 heterozygous females with measured baseline activities of 0.9 and 1.18 U / g Hb
§ In Cambodia, the median G6PD activity of a normal population is 12 U / g Hb