. 2021 Sep 8;17(9):e1009783. doi: 10.1371/journal.pgen.1009783

Table 2. Mean point estimates, standard errors and coverage (of 95% confidence interval) for the CAT, GMTE(1), GMTE(0) RGMTE and MR estimates across six simulation scenarios.

In each case, the true GMTE is fixed at -0.5. Unbiased estimates and associated standard errors/coverages are highlighted in bold.

Scenario & Assumption(s) violated		Estimator
Scenario & Assumption(s) violated		CAT	GMTE(1)	GMTE(0)	RGMTE	MR
1. PG3	Est.	-0.502	-0.755	-0.248	-0.507	-4.068
	S.E	0.150	0.093	0.025	0.096	0.350
	Cov^ge	0.95	0.22	0	0.95	0.00
2. NUC	Est.	0.255	-0.498	0.000	-0.498	-0.497
	S.E	0.140	0.089	0.025	0.092	0.320
	Cov^ge	0.00	0.96	0	0.95	0.94
3. PG1	Est.	-0.499	-0.502	0.000	-0.502	-0.501
	S.E	0.050	0.063	0.028	0.069	0.081
	Cov^ge	0.95	0.95	0	0.95	0.96
4. PG1 and NUC	Est.	-0.195	-0.568	-0.045	-0.523	-0.497
	S.E	0.050	0.061	0.028	0.067	0.079
	Cov^ge	0.00	0.79	0	0.93	0.94
5. PG2 & Hom	Est.	-1.270	-0.493	-0.001	-0.492	-0.883
	S.E	0.050	0.063	0.028	0.069	0.083
	Cov^ge	0.00	0.95	0	0.94	0.01
6. All except PG1	Est.	-1.458	-0.719	-0.223	-0.496	-3.728
	S.E	0.150	0.092	0.025	0.095	0.360
	Cov^ge	0.00	0.34	0	0.96	0.00