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. 2021 Sep 8;17(9):e1009783. doi: 10.1371/journal.pgen.1009783

Table 3. Mean point estimates, standard errors, coverage (of 95% confidence interval) and heterogeneity test rejection rates for the five combined estimates across six simulation scenarios.

In each case, the true GMTE is fixed at -0.5. Unbiased estimates and associated standard errors/coverage are highlighted in bold.

Scenario & Assumption(s) violated Estimator
RGMTE/MR RGMTE/CAT MR/CAT GMTE1/CAT RGMTE/MR/CAT
1. PG3 Est. -0.754 -0.506 -1.041 -0.684 -0.684
S.E 0.092 0.080 0.140 0.079 0.078
Covge 0.22 0.96 0.02 0.35 0.35
Qp ≥ 0.05 0.00 0.94 0.00 0.70 0.00
2. NUC Est. -0.498 -0.274 0.134 -0.286 -0.286
S.E 0.089 0.077 0.130 0.075 0.075
Covge 0.96 0.15 0.01 0.16 0.16
Qp ≥ 0.05 0.94 0.00 0.42 0.00 0.01
3. PG1 Est. -0.501 -0.500 -0.500 -0.500 -0.500
S.E 0.052 0.040 0.042 0.039 0.036
Covge 0.93 0.95 0.91 0.94 0.92
Qp ≥ 0.05 0.95 0.95 0.98 0.96 0.96
4. PG1 and NUC Est. 0.512 -0.313 -0.282 -0.346 -0.350
S.E 0.051 0.040 0.042 0.039 0.036
Covge 0.94 0.01 0.00 0.02 0.02
Qp ≥ 0.05 0.94 0.04 0.07 0.00 0.01
5. PG2 & Hom Est. -0.652 -1.001 -1.167 -0.969 -0.979
S.E 0.053 0.040 0.043 0.039 0.036
Covge 0.19 0.00 0.00 0.00 0.00
Qp ≥ 0.05 0.05 0.00 0.01 0.00 0.00
6. All except PG1 Est. -0.709 -0.761 -1.813 -0.913 -0.905
S.E 0.092 0.081 0.140 0.079 0.079
Covge 0.37 0.11 0.00 0.00 0.00
Qp ≥ 0.05 0.00 0.00 0.00 0.01 0.00