Figure 3. Increased neutralisation potency of APN01 towards SARS-CoV-2 variants.

(a) Table depicts source of the tested viral isolates, as well as multiplicity of infection (MOI) and the infection time used in these experiments for both VeroE6 and Calu-3 cells. (b) Panels depict both neutralization of the indicated SARS-CoV-2 isolates (blue line) as well as cytotoxicity of APN01 (red line) in VeroE6 cells. Analysis was done in quadruplicate with mean and standard deviations shown. Y-axis depicts the percentage of neutralization and cytotoxicity, respectively. (c) Table depicts IC₅₀ and IC₉₀ values for APN01 mediated neutralization of viral infection in VeroE6 and Calu-3 cells. (d) Same as (a) but conducted with epithelial lung cancer cell line Calu-3.