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[Preprint]. 2021 Sep 12:2021.09.08.21263284. [Version 1] doi: 10.1101/2021.09.08.21263284

Figure 4. Comparison of immune transcriptomes between COVID-19 recovered and SARS-CoV-2 naïve cohorts after receiving the BNT162b booster.

Figure 4.

a. Heatmaps showing log2 FC (top, red) and corresponding P.adj (bottom, ocher) of significantly upregulated genes between Day0 and Day1 in COVID-19 recovered (left) and SARS-CoV-2 naïve (right) cohorts. The genes specifically activated between day0 and day1 and still induced by day7 are listed in Supplementary Table 11–12. b. Venn diagram displays the number of significantly induced genes between Day0 and Day1 in both cohorts. The genes in each part are listed in Supplementary Table 13 and their GSEA analysis is in Supplementary Figure 4. c. Heatmaps showing log2 FC (top) and corresponding P.adj (bottom) of genes significantly activated at day7 in COVID-19 recovered (left) and SARS-CoV-2 naïve (right) cohorts. The genes induced between day0 and day7 fall into different categories based on their activation pattern (Supplementary Table 11–12). Group A, genes whose activation progresses between day0 and day7; Group B, genes highly activated preferentially between day0 and day1; Group C, genes highly activated between day1 and day7. d. Genes categorized in c were significantly enriched in Hallmark gene sets. X-axis denotes statistical significance as measured by minus logarithm of FDR q-values.