Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jul 30;17(9):957–967. doi: 10.1080/1744666X.2021.1953981

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

PMC Copyright notice

Figure 1. — Free ferric (Fe3+) iron is bound to the transporter protein, transferrin, in the circulation. Transferrin bound iron can then enter the cell through the membrane transferrin receptor (TfR). Iron is exported from the cell by Ferroportin (FPN). Excessive free iron may be sequestered by lipocalin, which is released on innate immune system activation. Iron may also be bound to soluble transferrin receptors (sTfR) in the circulation. Fe, Free Ferric (Fe3+) iron; FPN, Ferroportin; Tf, Transferrin; TfR, Transferrin receptor; sTfR, soluble transferrin receptor; LCN-2, Lipocalin-2