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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: J Neurosci Res. 2020 Jul 30;100(1):183–190. doi: 10.1002/jnr.24704

Figure 3: KOR antinociception varies with the X chromosome, not Y chromosome.

Figure 3:

A) In the XY*model, baseline tail withdrawal latencies were not significantly between any of the genotypes, n=6-11. B) U50 antinociception (10mg/kg, s.c.) tended to be lower in animals with two X chromosomes compared to 1 X chromosome. The presence or absence of the Y chromosome (SRY) did not affect withdrawal thresholds, n=6-11. C) Tail withdrawal thresholds 20 minutes following U50 administration were transformed to percent maximum effect (%MPE), n=6-11. Data presented as mean +/− SEM. Data were compared with 2 or 3-way ANOVA, with time, X chromosome, and Y chromosome as independent factors.