Table 1. Summary of studies selected for the variable left ventricular fractional shortening (FS%).

Author (year)	Type of exercise	Intervention protocol	DOX injection	Left ventricular fractional shortening (FS%)
				Control + DOX		Aerobic exercise + DOX
				n	${\overline{\text{X}}}_{\text{SD}}$	n	${\overline{\text{X}}}_{\text{SD}}$
Hayward et al. (2012)18	Aerobic Running wheel	Free access 24h/day Total: 10 weeks	2 mg/kg for 7 days Total = 14 mg/kg during exercise	15	52 ± 38	17	61 ± 29
Hydock et al. (2012) (a)19	Aerobic Running wheel	Free access 24h/day Total: 10 weeks	1 mg/kg for 15 days Total = 15 mg/kg during exercise	15	45 ± 3	9	46 ± 4
Hydock et al. (2012) (b)19	Aerobic Running wheel	Free access 24h/day Total: 10 weeks	2.5 mg/kg weekly for 6 weeks Total = 15 mg/kg during exercise	10	52 ± 5	10	61 ± 4
Calvé et al. (2012) (a)20	Aerobic Swimming	1h/day Total: 4 weeks	3 mg/kg on the 26th day of life pre-exercise	8	53.1 ± 3.8	8	49.5 ± 2.2
Calvé et al. (2012)(b)20	Aerobic Swimming	1h/day Total: 4 weeks	3 mg/kg on the 26th day of life pre-exercise	8	47 ± 2.1	8	51.6 ± 1.7
Dolinsky et al. (2013)21	Aerobic Treadmill	10-18 m/min 5 days/week Total: 8 weeks	8 mg/kg per week for 4 weeks Total = 32 mg/kg pre-exercise	8	23.8 ± 1.0	8	28.0 ± 0.7
Jensen et al. (2013) (a)22	Aerobic Treadmill	13-30 min/m 5⁰-18⁰ 20-60 min/day 5 days/week Total: 10 weeks	10 mg/kg single dose post exercise	8	50.47 ± 2.77	4	61.60 ± 7.28
Jensen et al. (2013) (b)22	Aerobic Running wheel	Free access 24h/day Total: 10 weeks	10 mg/kg single dose post exercise	8	50.47 ± 2.77	7	58.3 ± 4.33
Parry et al. (2015)23	Aerobic Running wheel	Free access 24h/day Total: 11 weeks	12 mg/kg single dose post exercise	6	59 ± 6†	4	63 ± 4†
Lien et al. (2015) (a)24	Aerobic Treadmill	18-24 m/min Total: 5 days	10 mg/kg single dose post exercise	10	48 ± 4	10	56 ± 4
Lien et al. (2015) (b)24	Aerobic Running wheel	Free access 24h/day Total: 5 days	10 mg/kg single dose post exercise	10	48 ± 4	10	51 ± 5
Lien et al. (2015) (c)24	Aerobic Treadmill	18-24 m/min Total: 5 days	15 mg/kg single dose post exercise	13	39 ± 6	13	48 ± 5
Lien et al. (2015) (d)24	Aerobic Running wheel	Free access 24h/day Total: 5 days	15 mg/kg single dose post exercise	13	39 ± 6	12	45 ± 3

DOX: doxorubicin; x: mean; SD: standard deviation;

^†measurement done on the 5th day after DOX injection;

(a), (b), (c), (d) are subdivisions of the studies conducted by Hydock et al.¹⁹ (2012), Calvé et al.²⁰ (2012), Jensen et al.²² (2013), and Lien et al.²⁴ (2015).