Table 3.
Median (IQR) IgG levels, fold RBD-ACE2 inhibition, and SARS-CoV-2 neutralization titers five weeks after resolution of COVID-19 symptoms according to clinical symptoms in non-hospitalized subjects
| N | Anti-Spike a | Anti-NTD a | Anti-RBD a | Anti-N a | ACE-2 Inhib. | Neut. Titer | |
|---|---|---|---|---|---|---|---|
|
| |||||||
| All subjects | 94 | 19 (7.0, 35) | 0.27 (0.10, 0.69) | 5.1 (1.8, 12) | 31 (11, 51) | 73 (20, 287) | 20 (10, 40) |
| Fever | 59 | 29 (7.9, 39) ** | 0.41 (0.17, 0.86) ** | 9.2 (2.8, 14) ** | 40 (23, 54) * | 121 (37, 328) ** | 20 (10, 80) *** |
| Chills b | 59 | 21 (7.9, 39) | 0.32 (0.14, 0.82) | 5.9 (2.1, 14) | 38 (16, 53) | 73 (34, 305) | 20 (10, 80) * |
| Productive cough | 37 | 26 (10, 38) | 0.44 (0.18, 0.74) * | 8.7 (3.2, 13) * | 42 (23, 55) | 131 (42, 305) * | 20 (10, 80) ** |
| Dry cough | 58 | 26 (10, 38) ** | 0.32 (0.17, 0.73) * | 7.4 (2.8, 13) ** | 39 (21, 53) | 124 (37, 298) * | 20 (10, 40) * |
| Shortness of breath | 47 | 26 (6.7, 38) | 0.27 (0.12, 0.74) | 5.9 (1.8, 13) | 27 (11, 56) | 85 (22, 305) | 20 (10, 80) |
| Chest tightness | 60 | 21 (7.2, 35) | 0.26 (0.09, 0.71) | 5.8 (1.8, 13) | 36 (12, 56) | 79 (21, 287) | 20 (10, 40) |
| Sore throat | 45 | 22 (8.4, 35) | 0.34 (0.17, 0.68) | 6.9 (2.4, 12) | 38 (14, 53) | 73 (20, 298) | 20 (10, 40) |
| Loss of taste or smell | 58 | 21 (8.0, 36) | 0.33 (0.10, 0.73) | 5.0 (1.8, 13) | 31 (14, 54) | 73 (22, 298) | 20 (10, 40) |
| Runny or stuffed nose | 54 | 20 (6.7, 37) | 0.28 (0.09, 0.69) | 5.5 (1.7, 12) | 35 (16, 53) | 73 (20, 279) | 20 (10, 40) |
| Body aches | 69 | 24 (8.4, 39) ** | 0.29 (0.14, 0.86) * | 6.9 (2.2, 14) ** | 38 (16, 53) | 93 (28, 298) * | 20 (10, 80) * |
| Headaches | 68 | 24 (9.1, 35) * | 0.31 (0.16, 0.71) * | 6.8 (2.9, 13) ** | 36 (18, 53) | 92 (26, 293) | 20 (10, 40) * |
| Low appetite | 59 | 27 (9.8, 43) *** | 0.41 (0.18, 1.0) *** | 8.7 (2.9, 16) *** | 40 (22, 56) ** | 123 (28, 311) ** | 20 (10, 80) *** |
| Nausea | 32 | 29 (9.2, 46) * | 0.45 (0.26, 1.1) ** | 9.1 (3.5, 14) * | 42 (26, 56) * | 95 (19, 332) | 20 (10, 80) |
| Vomiting | 13 | 30 (20, 43) * | 0.93 (0.44, 1.1) *** | 10 (4.8, 20) * | 48 (42, 82) ** | 131 (26, 376) | 40 (10, 80) |
| Abdominal pain | 17 | 35 (17, 47) * | 1.0 (0.28, 1.6) ** | 14 (5.6, 20) * | 48 (29, 69) * | 310 (47, 756) * | 80 (20, 80) ** |
| Diarrhea | 42 | 28 (13, 43) ** | 0.44 (0.23, 0.93) ** | 8.9 (4.1, 14) * | 41 (23, 82) ** | 124 (47, 392) ** | 30 (10, 80) * |
a
Values are x105
b
Data missing for three subjects
*
p<0.05
**
p<0.01
***
p<0.001