TABLE 4.

Multiple linear regression of symptoms associated with antibody levels, ACE-2 inhibition, and viral neutralization titers five weeks after resolution of COVID-19 symptoms in non-hospitalized subjects

Symptom ^a	sqrt[IgG(Spike)]				log[IgG(NTD)]				sqrt[IgG(RBD)]
Symptom ^a	β	95% CI	p	Adj. R²	β	95% CI	p	Adj. R²	β	95% CI	p	Adj. R²

Fever	314	13, 614	0.041	0.14	0.73	0.16, 1.29	0.012	0.19	254	55, 452	0.013	0.21
Chills	207	−124, 539	0.217	0.12	0.28	−0.36, 0.91	0.385	0.13	143	−80, 366	0.205	0.16
Productive cough	167	−152, 487	0.300	0.10	0.49	−0.11, 1.09	0.108	0.14	82	−133, 297	0.448	0.14
Dry cough	363	60, 666	0.020	0.15	0.68	0.11, 1.26	0.021	0.18	164	−44, 371	0.120	0.16
Shortness of breath	71	−229, 372	0.637	0.09	−0.02	−0.59, 0.56	0.955	0.11	−2	−204, 200	0.982	0.14
Chest tightness	193	−117, 503	0.219	0.11	0.11	−0.48, 0.71	0.713	0.11	87	−122, 297	0.407	0.14
Sore throat	51	−244, 346	0.730	0.09	−0.06	−0.62, 0.51	0.844	0.11	10	−188, 208	0.922	0.14
Loss of taste/smell	419	123, 715	0.006	0.18	0.70	0.13, 1.27	0.017	0.18	279	81, 478	0.007	0.22
Runny/stuffed nose	42	−263, 347	0.786	0.09	−0.03	−0.61, 0.55	0.920	0.11	26	−179, 231	0.802	0.14
Body aches	638	308, 968	<0.001	0.24	1.07	0.43, 1.71	0.001	0.23	377	151, 603	0.001	0.25
Headaches	512	202, 821	0.002	0.21	0.86	0.26, 1.46	0.005	0.20	285	73, 497	0.009	0.21
Low appetite	527	239, 815	<0.001	0.23	1.05	0.51, 1.59	<0.001	0.26	351	158, 544	0.001	0.27
Nausea	238	−67, 543	0.124	0.12	0.62	0.05, 1.19	0.035	0.17	124	−82, 330	0.235	0.15
Vomiting	205	−225, 634	0.345	0.10	1.02	0.23, 1.80	0.012	0.19	171	−116, 458	0.238	0.15
Abdominal pain	197	−194, 588	0.320	0.10	0.32	−0.43, 1.06	0.396	0.12	144	−118, 406	0.276	0.15
Diarrhea	258	−52, 569	0.101	0.12	0.21	−0.39, 0.81	0.483	0.12	143	−66, 352	0.177	0.16
Moderate disease	482	34, 930	0.035	0.14	0.57	−0.29, 1.44	0.191	0.13	302	−0.1, 604	0.050	0.18
Number of symptoms	95	52, 138	<0.001	0.28	0.17	0.08, 0.25	<0.001	0.27	56	27, 86	<0.001	0.28

Symptom ^a	sqrt[IgG(Nucleocapsid)]				log[ACE2 Inhibition]				log[Neut Titer]
Symptom ^a	β	95% CI	p	Adj. R²	β	95% CI	p	Adj. R²	β	95% CI	p	Adj. R²

Fever	340	−40, 721	0.079	0.15	0.80	0.13, 1.48	0.020	0.20	1.15	0.50, 1.80	0.001	0.22
Chills	257	−162, 676	0.226	0.14	0.47	−0.27, 1.21	0.212	0.18	0.52	−0.23, 1.27	0.168	0.13
Productive cough	121	−282, 525	0.551	0.11	0.46	−0.26, 1.18	0.209	0.16	0.78	0.08, 1.48	0.029	0.15
Dry cough	150	−244, 544	0.450	0.12	0.72	0.03, 1.41	0.040	0.19	0.71	0.02, 1.40	0.044	0.14
Shortness of breath	−222	−597, 152	0.241	0.13	−0.03	−0.71, 0.65	0.922	0.14	−0.02	−0.71, 0.66	0.947	0.09
Chest tightness	158	−234, 550	0.424	0.12	0.22	−0.49, 0.92	0.544	0.14	0.37	−0.34, 1.07	0.304	0.11
Sore throat	−111	−482, 259	0.550	0.11	−0.06	−0.73, 0.60	0.855	0.14	−0.03	−0.70, 0.64	0.926	0.09
Loss of taste/smell	380	−1, 762	0.051	0.15	0.73	0.04, 1.41	0.037	0.19	0.87	0.18, 1.56	0.014	0.16
Runny/stuffed nose	129	−254, 512	0.504	0.11	−0.07	−0.76, 0.62	0.834	0.14	−0.05	−0.74, 0.63	0.879	0.09
Body aches	406	−39, 850	0.073	0.15	0.88	0.10, 1.67	0.029	0.20	1.16	0.39, 1.94	0.004	0.19
Headaches	423	18, 828	0.041	0.16	0.89	0.17, 1.61	0.016	0.21	1.10	0.41, 1.78	0.002	0.20
Low appetite	429	49, 809	0.028	0.17	0.99	0.33, 1.66	0.004	0.23	1.08	0.41, 1.75	0.002	0.20
Nausea	328	−55, 710	0.092	0.14	0.01	−0.69, 0.71	0.981	0.14	0.34	−0.36, 1.03	0.338	0.11
Vomiting	517	−12. 1047	0.055	0.15	−0.12	−1.10, 0.85	0.799	0.14	0.16	−0.83, 1.15	0.749	0.10
Abdominal pain	110	−385, 604	0.660	0.11	0.25	−0.63, 1.14	0.571	0.14	0.63	−0.22, 1.47	0.144	0.12
Diarrhea	316	−74, 707	0.110	0.14	0.43	−0.28, 1.13	0.230	0.16	0.40	−0.31, 1.10	0.269	0.11
Moderate disease	476	−94, 1047	0.100	0.14	1.35	0.36, 2.34	0.008	0.22	1.23	0.21, 2.26	0.019	0.16
Number of symptoms	77	19, 135	0.010	0.19	0.14	0.04, 0.25	0.007	0.22	0.19	0.09, 0.29	<0.001	0.24

All models adjusted for age, sex, BMI, and Charlson Comorbidity Index Score