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Overview of the physiologically based pharmacokinetic model development, verification, and application strategy.6, 7, 8, 9 AGP, α1‐acid glycoprotein; CYP, cytochrome P450; DDI, drug–drug interaction; fup, free fraction in plasma protein; MAD, multiple‐ascending dose; MBI, mechanism‐based inactivation; OCT2, organic cation transporter 2; Pgp, P‐glycoprotein; PM, poor metabolizer; SAD, single‐ascending dose
