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. 2021 Sep 13;2021:5554259. doi: 10.1155/2021/5554259

Table 4.

The preventive effects of A. cepa and its constituents on lung cancer and lung infections.

Study type Study design Preparations Dose Effects Ref.
Rats exposed to nicotine A. cepa oil 100 mg/kg b.w., 21 days Increased CAT and SOD activity in the lung tissue [101]
Exp Mice Qt Decreased superoxide radicals and LPO; lung morphological changes [110]
Swiss albino male mice Qt Lowered the lipid peroxide levels [111]
Cell line NCI-H209 Qt glucuronides Qt glucuronides inhibited proliferation through G2/M arrest of the cell cycle and induced apoptosis via caspase-3 cascade in the human lung cancer cell line NCI-H209 [99]
Cat fish A. cepa extract 1000 mg/ml Antibacterial activity [98]
Mice Ethanol extract 10 and 20 mg/ml Antibacterial effect [150]
Mesocestoides corti infection in BALB/c mice Qt 5.0–20.0  mg/kg, oral Decreased peripheral blood eosinophilia and IgE hyperproduction [135]
Clin Lung cancer patients A. cepa extracts 10 g L−1 Antiproliferative capacity; decreased mitotic indices [98]
Adenocarcinoma patients Qt-rich food Decreased lung cancer risk; upregulated GSTM1, GSTM2, GSTT2, and GSTP1; downregulated specific P450 genes [102]
Lung cancer patients Qt-rich food mg/100 g Decreased carcinogenesis-related miR-146, miR-26, and miR-17 families [151]
DPT patients Qt and QP 5 g in 100 mL saline Reduction of the disease manifestation [115]
Cell line NCI-H209 Qt glucuronides Qt glucuronides inhibited proliferation through G2/M arrest of the cell cycle and induced apoptosis via caspase-3 cascade in the human lung cancer cell line NCI-H209 [99]
Clinical study A. cepa aqueous extract Antibacterial effect on Gram-positive and Gram-negative bacteria; effect on A549 lung cancer cell lines [100]
Virus-infected patients Inhaled onion, garlic extract Improved all respiratory symptoms [107]
Clinical study Vitamin C and Qt 30 or 40 mg/kg, 4 days Treatment of respiratory tract infections with COVID-19 [112]
Clinical study Qt and NAC, nebulized 600 and 300 mg/mL for Qt and NAC Decreased respiratory symptoms; antiviral in COVID-19 infection [114]

Ref.: references, Exp: experimental, and Clin: clinical.