Table 1.
TLR member | TLR expression | TLR coreceptor | Gene & its location | Origin | TLR active form | Signaling adaptors |
---|---|---|---|---|---|---|
TLR1 | Cell membrane | TLR2 |
TLR1-6-10
4p14 |
Nonviral | TLR1-TLR2 | BCAP, TIRAP, MyD88, SCIMP |
TLR2 | Cell membrane | TLR1, 2, 6 & 10 CD14, CD36, integrin, RP105, MBL, LBP |
TLR2
4q31.3 |
Nonviral | TLR1-TLR2 TLR2-TLR2 TLR2-TLR6 TLR2-TLR10 |
BCAP, TIRAP, MyD88, SCIMP |
TLR3 | Endoplasmic reticulum, lysosomal membrane | CD14, Mex3B |
TLR3
4q35.1 |
Viral | TLR3-TLR3 | SARM, SCIMP, TRIF, TICAM1 |
TLR4 | Cell membrane, endoplasmic reticulum, lysosomal membrane | MD2, LY96, CD14, CD36, LBP, RP105 |
TLR4
9q33.1 |
Nonviral | TLR4/MD2-TLR4/MD2 TLR4-TLR6 |
BCAP, TIRAP, MyD88, SARM, SCIMP, TICAM1, TICAM2 |
TLR5 | Cell membrane |
TLR5
1q41 |
Nonviral | TLR5-TLR5 | MyD88, TICAM1 | |
TLR6 | Cell membrane | TLR2, CD36, LBP |
TLR1-6-10
4p14 |
Nonviral | TLR2-TLR6 TLR4-TLR6 |
BCAP, TIRAP, MyD88, SCIMP |
TLR7 | Cell membrane, endoplasmic reticulum, lysosomal membrane | CD14 |
TLR7
Xp22.2 |
Viral | TLR7-TLR7 | MyD88 |
TLR8 | Endoplasmic reticulum, lysosomal membrane |
TLR8
Xp22.2 |
Viral | TLR8-TLR8 | MyD88 | |
TLR9 | Endoplasmic reticulum, lysosomal membrane | CD14 |
TLR9
3p21.2 |
Viral | TLR9-TLR9 | TIRAP, MyD88, SCIMP |
TLR10 | Cell membrane, endoplasmic reticulum, lysosomal membrane |
TLR1-6-10
4p14 |
Nonviral | TLR1-TLR10 TLR2-TLR10 TLR10-TLR10 |
MyD88 |