Table 4.

Summary of therapeutics targeting TLRs in CRC.

Compound	Target TLRs	Drug	Clinical phase
BCG	TLR2/4	Synthetic ssRNA	Phase I
MPL	TLR4	Synthetic ssRNA	Phase I
CBLB502	TLR5	Flagellin	Phase I
Imiquimod	TLR7	Small molecule ssRNA	Phase I/II/III
IMO2055	TLR9	CpG oligonucleotide	Phase I/II
MGN1703	TLR9	dSLIM	Phase II

References: Hennessy et al.,[130]; Gambara et al.,[129]; Vacchelli et al., [131]; Kaczanowska et al.,[124]; Moossavi et al., [125]; Li et al., [23]; Pradere et al., [74]; Gao et al., [51]; Braunstein et al.,[122].