Figure 2.

P5C3 demonstrates potent and broad neutralizing activity against spike-coated pseudoviruses

(A) Neutralization of lentiviral particles pseudotyped with SARS-CoV-2 Spike expressing variants of concern in a 293T-ACE2 infection assay. All Spike proteins with mutations except Q493K and S494P contained the D614G substitution that became dominant early in the pandemic. Results shown are the average of two independent experiments with each concentration response tested in triplicate. Mean values ± SEM are shown.

(B) Heatmap showing EC₅₀ and EC₈₀ neutralization potencies for the indicated mAbs. Results are the average of two to four independent experiments with each concentration response tested in duplicates or triplicates.