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. 2021 Sep 21;37(2):109814. doi: 10.1016/j.celrep.2021.109814

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© 2021 The Author(s)

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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P5C3 LS demonstrates potent neutralizing activity against SARS-CoV-2 VOCs

(A) Neutralization activity of mAbs performed in a live SARS-CoV-2 infectious virus cytopathic effect assay. The indicated SARS-CoV-2 variants were used to infect Vero E6 in vitro in the absence and presence of concentration response of the indicated mAb evaluated in duplicates or triplicates.

(B) Heatmap showing EC₅₀ and EC₈₀ neutralization potencies for the mAbs indicated in pseudoviral assay produced using the indicated mutated version of Spike. Results shown are the average of two to four independent experiments with each concentration response tested in duplicates or triplicates. Mean values ± SEM are shown.