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Regulatory T-cells in CVID. A Gating strategy and proportion of CD25 + FOXP3 + T-cells within CD4 + population. B Expression of CTLA4, ICOS, TIGIT, and T-BET in the Treg population. C Decreased fraction of CTLA4 + Tregs was confined to the CD27 + population. CVIDid = CVID with immune dysregulation (n = 20), CVIDio = CVID with infections only (n = 12), HC = healthy controls (n = 12). Statistics: Mann–Whitney U-test. *p < 0.05, **p < 0.01, ***p < 0.001
