Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Sep 20;12:5533. doi: 10.1038/s41467-021-25844-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — a Homozygous ΔLARM2 mouse forelimb (FL) and hindlimb (HL) autopods showing loss of dosalization exclusively in the anterior aspect at 6 weeks (left), reduced anterior expression of Lmx1b in e12.5 limb buds (middle) and ventral-ventral morphology specifically in anterior 1–3 digits (right). b Homozygous ΔLARM1 mouse showing loss of dorsalization that is accentuated posteriorly at 6 weeks (left), reduced posterior expression of Lmx1b in e12.5 limb buds (middle) and ventral-ventral morphology specifically in digits 2–5 (right). Note the progressive loss of dorsalization towards digit 5 (e.g., increasing size of duplicated ventral sesamoid bones). c Equivalent views of a wild-type littermate for comparison. Arrowheads highlight the duplicated ventral sesamoid bones and distal phalanges.