Figure 2.

IgG and neutralizing antibodies induced by intranasal vaccination in mice. (A) Specific humoral immunity on day 14 (14 days after the initial immunization) and day 35 (14 days after the immunization boost). (B) The serum neutralizing titers against hRSV A Long were measured at day 35. The titers are presented as the dilution factors resulting in a 50% reduction in plaque numbers. Statistically significant differences were appropriately determined by one-way ANOVA, ***p < 0.001. The lines represent the median and interquartile range, and the bars represent the mean values with standard deviations.