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. 2021 Sep 20;4:1101. doi: 10.1038/s42003-021-02633-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Separate cohorts of mice were treated with LT3 and LT4 (10 mg kg⁻¹) for seven days, and the a theta waves frequency events and b total theta frequencies were recorded and analyzed (n = 12 mice/group; a repeated measures two-way ANOVA, F _(1,22) = 11.3, P = 0.003; b repeated measures two-way ANOVA, F _(2,33) = 0.105, P = 0.901). Values are presented as the mean ± S.E.M. *P < 0.05 and ***P < 0.01 (relative to WT), by repeated measures two-way ANOVA with Bonferroni’s multiple comparison tests. LT3 and LT4 normalized the theta waves in THRSP OE mice similar to WT-VEH.