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. 2021 Sep 20;12:5530. doi: 10.1038/s41467-021-25708-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Unsupervised analysis of 32 RIG tumors was conducted based on the 10,000 most variably methylated probes. Through a t-SNE analysis, the majority of RIG tumors form a homogenous group of tumors resembling the pediatric GBM RTK1 group. ALL-RIG and MB-RIG samples were compared with 120 well-characterized reference samples representing CNS tumors of known histological and/or molecular subtype. PXA pleiomorphic xanthoastrocytoma, pedGBM_RTK1 pediatric glioblastoma subclass RTK1, pedGBM_RTK2 pediatric glioblastoma subclass RTK2, pedGBM_MYCN pediatric glioblastoma subclass MYCN, DMG_K27 diffuse midline glioma H3 K27 mutant, GBM_G34 glioblastoma, H3.3 G34 mutant.