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. 2021 Sep 20;12:5530. doi: 10.1038/s41467-021-25708-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — T-SNE analysis of primary MB and post-MB RIG compared with existing MB subgroups (a) and representative copy-number profile (b) reveal distinct genome-wide methylation patterns and recurrent high-level PDGFRA amplification and CDKN2A/B deletion. Available primary MB and post-MB RIG samples (n = 11 pairs) were investigated with 100 MB reference samples representing established MB subtypes^57,70. MB and RIG pairs from our series were encircled and linked with dotted lines. Histological staining for hematoxylin and eosin (c) of two paired primary medulloblastoma and radiation-induced gliomas (MB/RIG_28, MB/RIG_29) display distinct morphological characteristics. Scale bar represents 200 μm. T-SNE t-stochastic neighboring embedding, MB medulloblastoma, MB-SHH-INF medulloblastoma sonic-hedgehog infant subgroup, MB-SHH-AD medulloblastoma sonic-hedgehog adult subgroup, CNP copy-number profile.