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. 2021 Sep 20;11:18643. doi: 10.1038/s41598-021-97136-3

Table 3.

The association of loneliness and a feeling of increased social isolation with pain intensity.

Degree of loneliness
None
(3 points)
n = 14,277
Mild
(4–5 points)
(n = 3250)
Moderate-to-severe
(6–15 points)
n = 7955
P for trend
Adjusted mean SE Adjusted mean SE Adjusted mean SE
Pain intensity for total participants, n = 25,482
Model 1 1.3 0.01 1.5*** 0.01 1.7*** 0.01  < 0.001
Model 2 1.3 0.01 1.5*** 0.01 1.6*** 0.01  < 0.001
Pain intensity for participants with any pain symptoms, n = 15,541
Model 1 1.5 0.01 1.6*** 0.02 1.8*** 0.01  < 0.001
Model 2 1.5 0.01 1.6*** 0.01 1.8*** 0.01  < 0.001
Frequency of feelings of increased social isolation during the COVID-19 pandemic
Never n = 18,168 Rarely n = 3188 Sometimes n = 2454 Often n = 1033 Always n = 639 P for trend
Adjusted mean SE Adjusted mean SE Adjusted mean SE Adjusted mean SE Adjusted mean SE
Pain intensity total participants, n = 25,482
Model 1 1.4 0.01 1.5*** 0.01 1.6*** 0.01 1.8*** 0.02 2.0*** 0.03  < 0.001
Model 2 1.4 0.01 1.5*** 0.01 1.6*** 0.01 1.7*** 0.02 1.8*** 0.03  < 0.001
Pain intensity for participants with any pain symptoms, n = 15,541
Model 1 1.5 0.01 1.7*** 0.02 1.8*** 0.02 2.0*** 0.03 2.1*** 0.03  < 0.001
Model 2 1.6 0.01 1.7*** 0.01 1.8*** 0.02 1.9*** 0.03 2.0*** 0.03  < 0.001

Model 1: Adjusted for age and sex.

Model 2: Adjusted for age, sex, educational level, marital status, living alone, employment status, equivalized income, smoking status, alcohol consumption, physical activity, sleep duration, history of depression, and history of mental illnesses other than depression.

COVID-19 coronavirus disease 2019, OR odds ratio, CI confidence interval.

Loneliness was measured using the Japanese version of the University of California, Los Angeles Loneliness Scale (Version 3), Short Form 3-item assessment tool.

Pain symptoms were headache, neck/shoulder pain, upper limb pain, low back pain, leg pain, or the presence of chronic pain.

P values were calculated to compare participants who without loneliness / did not feel increased social isolation during the COVID-19 pandemic at all to those in the other categories using the analysis of covariance with Dunnett's test.

***p < 0.001. n = 25,482.