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. 2021 Sep 20;11:18587. doi: 10.1038/s41598-021-98131-4

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© The Author(s) 2021, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Analyzing candidate immune checkpoint molecules targeted by blockade in carcinomas. Carcinomas throughout the body were enrolled for analysis, and multiple systems showed various immune checkpoint molecule patterns. PD-L1 (A), CD112 (B), TNFRSF14 (C), TNFSF4 (D), TNFSF18 (E), CD48 (F), and LGALS9 (G) were analyzed for abnormal expression in breast carcinomas. In each image, the specific quantitative value is shown at the top, and each dot represents the expression in samples. The bar graphs below were used for comparison, and bar height bar represents the median expression of the specific tumor type or normal tissue. Specifically, CD112, TNFSF4, TNFSF18, and LGALS9 were relatively overexpressed in breast carcinomas.