Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Sep 20;11:18587. doi: 10.1038/s41598-021-98131-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Clinical evaluations of potential therapeutic candidates. Data were acquired from the combined study cohorts of BREAST (METABRIC 2016), BREAST CANCER (MSK 2018), and BREAST INVASIVE CARCINOMA BREAST (TCGA PANCAN 2018). The clinical significance of the cluster including TNFSF18 (A), LGALS9 (B), TNFSF4 (C) and CD48 (D) was analyzed for the value of these molecules as immunotherapeutic targets. The correlations between KRAS and TNFSF18 (E), LGALS9 (F), TNFSF4 (G) or CD48 (H) were analyzed, and the positive correlation between TNFSF4 and KRAS strongly suggested the prospective therapeutic effects of using TNFSF4 as target for manipulation or blockade. (I) A close correlation between TNFSF4 and ALDH1A1 expression was identified. Stem cells with a positive ALDH1A1 phenotype had a shorter survival time (J) and shorter progression-free time (K).