Table 2.

Altered variants of SKAT-O Significant Genes (DICER1, LRP1B) in paired samples.

Gene	P Value	Chromosome	Position	REF	Alt	Amino acid	SIFT	Polyphen2	CADD
DICER1	0.010	14	95,560,248	C	T	p.E1781K	0.1	0.818	23
		14	95,562,263	C	T	p.G1665E	0	0.916	29.4
		14	95,570,303	C	T	p.E1144K	0.03	0.19	20.4
		14	95,577,763	C	T	p.G716E	0.002	0.832	34
LRP1B	0.021	2	141,128,318	C	T	p.D3657N	0.02	0.832	26.6
		2	141,242,964	C	A	p.V3125F	0.01	0.312	33
		2	141,763,012	G	A	p.R799X	1	NA	38
		2	141,986,887	C	T	p.D239N	0	0.08	26.9
		2	142,012,117	A	T	p.I146K	0.01	0.184	23.6

Ref reference base, Alt alternative base, SIFT sorting intolerant from tolerant, CADD combined annotation dependent depletion.