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. 2021 Sep 20;12:5547. doi: 10.1038/s41467-021-25865-0

Fig. 2. Immunogenomic differences underlying the phenotypic signatures of the new IRs (LAG-3, TIM-3, and TIGIT).

Fig. 2

a Alteration landscape of 43 primary ccRCC tumour samples. Upper heatmap: nuclear grade, tumour stage, venous invasion, tumour size and information on the three IR signatures. b Genomic alteration differences in tumorigenic signalling pathways related to ccRCC development and the three IR (LAG-3, TIM-3, and TIGIT) signatures. The table shows the percentage of samples with alterations in each of the selected signalling pathways. p values were determined with a two-tailed Fisher’s exact test. c–f Positive cell densities and areas (CD34 and D2-40) in 105 ccRCC samples obtained from patients based on the three new IR clusters and the acquired immunity (c), innate immunity (d), inhibitory tumour metabolism (e), and vascular attribute (f) signatures. The lines within the boxes represent the medians, the upper and lower ends of the boxes represent the upper and lower quartiles, and the bars represent the minimum and maximum values in 1.5 times the IQR. p values were determined with a two-tailed Mann–Whitney U-test. Source data are provided as a Source data file.