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. 2021 Sep 20;12:5547. doi: 10.1038/s41467-021-25865-0

Fig. 4. Histological subtype-specific differences underlying the phenotypic signatures of the new IRs (LAG-3, TIM-3, and TIGIT).

Fig. 4

a Hierarchical clustering heatmap (low, blue; high, red) using positive-stained cell densities of LAG-3, TIM-3, and TIGIT in 41 non-ccRCC samples. Data were normalized prior to clustering. Samples were obtained from the papillary (n = 12), chromophobe (n = 12), sarcomatoid (n = 8), Xp11.2 translocation (n = 7), and collecting duct (n = 2) subtypes. b Inferred IR cluster distributions obtained in (a) by histological subtype.