Table 1.
Clinicopathological characteristics associated with the phenotypic signatures of the new IRs (LAG-3, TIM-3, and TIGIT) in 105 primary ccRCC tumour samples (COHORT 1).
| Characteristic | All patients (n = 105) | IR profile | p value | ||||
|---|---|---|---|---|---|---|---|
| LAG-3 n = 45 (43%) | TIM-3 n = 46 (44%) | TIGIT n = 14 (13%) | LAG-3 vs TIM-3 | LAG-3 vs TIGIT | TIM-3 vs TIGIT | ||
| Age, yr, median, (IQR) | 60 (52-70) | 63 (55-73) | 57 (52-70) | 54 (50-68) | 0.756 | 0.231 | 0.322 |
| Gender, no (%): | 0.247 | 1.000 | 0.515 | ||||
| Male | 76 (72%) | 35 (78%) | 30 (65%) | 11 (79%) | – | – | – |
| Female | 29 (28%) | 10 (22%) | 16 (35%) | 3 (21%) | – | – | – |
| Nuclear grade, no (%): | 0.668 | 0.109 | 0.192 | ||||
| G1 + G2 | 69 (66%) | 27 (60%) | 30 (65%) | 12 (86%) | – | – | – |
| G3 + G4 | 36 (34%) | 18 (40%) | 16 (35%) | 2 (14%) | – | – | – |
| Pathological T stage, no (%): | 0.290 | 0.354 | 0.756 | ||||
| pT1 + pT2 | 64 (61%) | 24 (53%) | 30 (65%) | 10 (71%) | – | – | – |
| pT3 + pT4 | 41 (39%) | 21 (47%) | 16 (35%) | 4 (29%) | – | – | – |
| Venous invasion, no (%): | 0.112 | 0.342 | 1.000 | ||||
| Yes | 30 (29%) | 17 (38%) | 10 (22%) | 3 (21%) | – | – | – |
| No | 75 (71%) | 28 (62%) | 36 (78%) | 11 (79%) | – | – | – |
| Tumour size, mm, median (IQR) | 59 (35–80) | 50 (31–74) | 68 (49–81) | 48 (30–81) | 0.186 | 0.658 | 0.177 |
p values were determined with a two-tailed Mann–Whitney U-test or Fisher’s exact test.