Figure 2.
Differential expression analysis using SSL-RNAs in PD. (a) Volcano plot of expression changes in PD. In the first cohort, 209 genes were downregulated (blue) and 74 genes were upregulated (red). In the second cohort, 308 genes were downregulated (blue) and 151 genes were upregulated (red). Genes with FDR < 0.25 were considered to have a significant change. (b) Heatmaps of oxidative phosphorylation-related genes. Expression levels were converted to z-scores by genes. The gray color indicates missing values. Ctrl healthy controls, FDR false discovery rate, NA not available, PD Parkinson’s disease. The plots were constructed using ggplot2 and gplots R package19,24.