Integrative modeling of PRC2.A, bead and density model of full-length PRC2, from the O-4 modelling trial. Subunits coloring: EZH2 in green, EED in red, RBAP48 in violet, SUZ12 in orange, AEBP2 in dark cyan. B, density of AEBP2209–503 from the O4 modeling trial overlaid on the high-resolution structure of PRC2 (PDB 6c23), colored as above, except with AEBP2440–503 in blue. Domain labels for EZH2 provided.