Table 1.

Clinicopathologic variables of 316 patients

Variable**	Median (range) or N (%)
Age (years, IQR)	53.4 (40–64)
Follow up (years)	5.77 (3–31.5)
Gender (Female)	163 (52%)
Bilateral	51 (16%)
RET Mutant	64 (21%)
Known Structural disease	80 (26%)
Tumor size (cm)	1.9 (1.1–3.2)
Node positive	169 (54%)
Positive Central Node	154 (49%)
Positive Lateral Node	112 (35%)
Persistent biochemical disease*	180 (62%)
Preop calcitonin (pg/ml), n=188	914 (258–4346)
Preop CEA (ng/ml), n=102	29 (6–92)
Post op calcitonin (pg/ml), n=294	32 (3–418)
Post op CEA (ng/ml), n=235	6 (2–17)
Neck Reoperation	70 (22%)
Neck external beam radiation	32 (10%)
Tyrosine Kinase Inhibitor	39 (12%)
Cytotoxic Chemotherapy	11 (4%)
Metastectomy	11 (4%)
Year of Surgery
1986–1996	35 (11%)
1997–2007	142(45%)
2008–2018	139 (44%)

^*Persistent biochemical disease was defined as an elevation above the upper limit of normal in the first postoperative calcitonin or CEA level; IQR=Inter-quartile ranges

^**For continuous variable, median and IQR were provided.