Fig. 7.

Representative images showing the different bone remodeling structures as a result of fluorochrome double labels (green). (A) Overhead view demonstrating that HO modeling was independent with minimal effect to the host bone, which had no labels. (B) Overhead view demonstrating bone modeling at the linea aspera (LA), periosteal reaction (PR), and drill hole (DH) defect regions. Osteonal (O) remolding was also observed mid-cortex. (C) Images showing a high magnification (100×) view of the different bone remodeling structures. Host cortical bone had standard osteonal remodeling comprised of small circular double labels. The periosteal modeling contained large circular double labels, similar to the host cortical bone. Remodeling near biofilm inocula demonstrated sheet-like double labels filling in the previously resorbed bone. Ectopic bone modeling resembled human HO similar to trabecular remodeling with linear double labels predominantly at the bone seams.