Table 2.

Bopta and Meb accumulation and decay parameters in livers and hepatocytes

Imaging agents	Bopta	Meb	p, Bopta versus Meb	Bopta
Livers	Normal	Normal		no Mrp2
T0,liver [min]	8.0 ± 0.5	5.5 ± 1.1	< 0.001	-
T0,HC [min]	4.7 ± 1.3	4.0 ± 1.5	.37	-
SlopeL1,liver [μM/min]	37 ± 5	333 ± 71	< 0.001	28 ± 6*
SlopeL1,HC [μM/min]	57 ± 16	452 ± 107	< 0.001	35 ± 8**
SlopeL2,liver [μM/min]	8 ± 1	16 ± 5	< 0.001	-
SlopeL2,HC [μM/min]	8 ± 2	22 ± 7	< 0.001	-
kel,liver [min−1]	0.09 ± 0.01	0.13 ± 0.02	< 0.001	-
kel,HC [min−1]	0.10 ± 0.02	0.16 ± 0.03	< 0.001	-
T1/2,liver [min]	7.6 ± 0.9	5.5 ± 0.7	< 0.001	-
T1/2,HC [min]	7.4 ± 1.3	4.5 ± 0.6	< 0.001	-
CLel,HC [mL/min]	0.95 ± 0.17	1.44 ± 0.26	< 0.001	-

Bopta and Meb accumulation in normal livers and hepatocytes fitted nonlinear regressions described by two lines L₁ and L₂ intersecting at T₀ or time when bile secretion started to impact the accumulation profile. During decay, liver and hepatocyte concentrations fitted a one-phase decay described by k_el and T_1/2. CL_el,HC was calculated by k_el · V_HC. Statistics between normal livers and livers lacking Mrp2 (column 2 versus column 5) are p < 0.010 (*) and p < 0.001 (**). CL_el,HC Elimination clearance from hepatocytes, k_el Elimination constant rate, HC Hepatocytes, T_1/2 Half-life of elimination, V_HC Hepatocyte volume