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. 2021 Sep 20;11:92. doi: 10.1186/s13550-021-00835-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Evaluation of cardiac [¹²³I]MIBG uptake in vehicle and doxorubicin-treated rats measured on SPECT images. a, b Cardiac [¹²³I]MIBG uptake monitoring during the 6 weeks of experimental protocol. Data are expressed as heart to mediastinum (H to M) ratio related to control group (a) and H to M ratio (b) and as mean ± SEM. p values presented on graphs are comparisons between control and doxorubicin groups. c Representative cardiac-centered coronal views of [¹²³I]MIBG SPECT-CT images in control (upper panel) and doxorubicin-treated rats (lower panel) obtained at 6 weeks