Table 2.

Parameter values used in the model of Bedessem and Stephanou in [19]. The Michaelis-Menten coefficients are abbreviated as MM

Parameter	Description	Value
$a_1$	Cyclin D synthesis rate	0.51
$a_2$	Cyclin D spontaneous degradation rate	1.00
$a_3{H}_0$	HIF-mediated degradation rate	$8.5\times {10}^{-3}$
$a_4$	Fitting parameter from HIF measurements	2.50
$b_1$	active E2F-induced and cell growth-dependent synthesis rate of cyclin E	$1.8\times {10}^{-2}$
$b_2$	Cyclin E spontaneous degradation rate	0.50
$c_1$	SCF activation rate	1.00
$c_2$	SCF inactivation rate	14.0
$J_1$	MM coefficient for SCF activation	0.04
$J_2$	MM coefficient for SCF activation	0.04
$d_1$	Unphosphorylated Rb synthesis rate	0.20
$d_2$	Cyclin D-mediated Rb phosphorylation rate	0.10
$d_3$	Unphosphorylated Rb spontaneous degradation rate	0.10
$e_1$	Cell growth rate	$5.0\times {10}^{-3}$
$M_e$	Maximal size of cell growth	10
$f_1$	E2F dephosphorylation rate	$1.6\times {10}^{-2}$
$E2F_{\mathit{tot}}$	Scaled sum of total E2F (both phosporylated and unphosphorylated)	1
$CYC{E}_{\mathit{thresh}}$	Cyclin E amount required for progression to S phase	0.15