Table 2.
The SMR analyses of COVID-19.
| Type | Data | Tissue | Ch | Gene | Top SNP | PGWAS | PeQTL | Beta | PSMR | PBonferroni | PHEIDI | NSNP |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| eQTL | CAGE | blood | 12 | OAS3 | rs7955267 | 1.08E-07 | 8.55E-33 | −0.288 | 1.22E-06 | 0.010 | 0.089 | 20 |
| eQTL | CAGE | blood | 17 | LRRC37A4P | rs113661667 | 1.01E-06 | 5.03E-228 | −0.095 | 1.34E-06 | 0.011 | 0.189 | 20 |
| eQTL | CAGE | blood | 17 | MGC57346 | rs79600142 | 1.38E-06 | 4.29E-157 | 0.110 | 2.03E-06 | 0.017 | 0.375 | 20 |
| eQTL | CAGE | blood | 19 | TYK2 | rs11085727 | 1.27E-07 | 5.69E-20 | −0.377 | 4.75E-06 | 0.040 | 0.058 | 15 |
| eQTL | CAGE | blood | 21 | IFNAR2 | rs2252639 | 1.08E-16 | 5.21E-34 | 0.464 | 7.26E-12 | 6.12E-08 | 0.017 | 9 |
| eQTL | Geuvadis | Lymphoblastoid Cell | 12 | OAS1 | rs1981555 | 3.10E-08 | 1.39E-14 | −0.189 | 6.99E-06 | 0.013 | 0.297 | 16 |
| eQTL | Geuvadis | Lymphoblastoid Cell | 17 | LRRC37A4P | rs62054835 | 1.66E-06 | 8.47E-28 | −0.120 | 1.14E-05 | 0.021 | 0.016 | 20 |
| eQTL | Geuvadis | Lymphoblastoid Cell | 21 | IFNAR2 | rs2300371 | 5.11E-08 | 3.88E-14 | −0.208 | 9.84E-06 | 0.018 | 0.098 | 12 |
| eQTL | Geuvadis | Lymphoblastoid Cell | 21 | IL10RB-AS1 | rs2300371 | 5.11E-08 | 4.93E-32 | 0.140 | 7.64E-07 | 1.42E-03 | 0.020 | 18 |
| mQTL | Hannon | blood | 3 | NA | rs34438204 | 4.86E-33 | 1.84E-25 | −12.75 | 3.71E-15 | 4.61E-10 | 0.031 | 20 |
| mQTL | Hannon | blood | 3 | NA | rs13085367 | 6.59E-19 | 6.77E-15 | −16.47 | 4.74E-09 | 5.88E-04 | 0.060 | 15 |
| mQTL | Hannon | blood | 3 | XCR1 | rs4443214 | 2.53E-20 | 1.87E-12 | 21.73 | 2.13E-08 | 2.64E-03 | 0.040 | 9 |
| mQTL | Hannon | blood | 3 | XCR1 | rs34438204 | 4.86E-33 | 7.29E-20 | 18.64 | 3.96E-13 | 4.91E-08 | 0.411 | 17 |
| mQTL | Hannon | blood | 3 | NA | rs35110864 | 2.78E-19 | 1.06E-64 | −7.46 | 2.08E-15 | 2.57E-10 | 0.020 | 20 |
| mQTL | Hannon | blood | 3 | NA | rs13433997 | 3.26E-34 | 1.49E-13 | −94.85 | 2.63E-10 | 3.26E-05 | 0.024 | 14 |
| mQTL | Hannon | blood | 3 | NA | rs9877748 | 2.05E-31 | 4.33E-94 | −5.12 | 3.51E-24 | 4.36E-19 | 0.018 | 20 |
| mQTL | Hannon | blood | 3 | NA | rs35775079 | 1.10E-13 | 4.06E-14 | 13.07 | 1.17E-07 | 0.014 | 0.145 | 8 |
| mQTL | Hannon | blood | 3 | NA | rs13069742 | 1.81E-31 | 1.10E-21 | −22.65 | 1.38E-13 | 1.71E-08 | 0.229 | 18 |
| mQTL | Hannon | blood | 3 | CCR5 | rs7642320 | 6.66E-28 | 3.25E-14 | −12.70 | 4.46E-10 | 5.54E-05 | 0.101 | 13 |
| mQTL | Hannon | blood | 3 | CCR5AS | rs7642320 | 6.66E-28 | 1.67E-11 | −18.20 | 9.76E-09 | 1.21E-03 | 0.073 | 7 |
| mQTL | Hannon | blood | 12 | OAS1 | rs10850097 | 1.01E-08 | 1.15E-30 | 5.63 | 2.92E-07 | 0.036 | 0.266 | 9 |
| mQTL | LBC-BSGS | blood | 17 | MAPT | rs112572874 | 3.29E-07 | 0 | −0.081 | 3.75E-07 | 0.034 | 0.070 | 20 |
| mQTL | LBC-BSGS | blood | 21 | IFNAR2 | rs2300370 | 7.27E-15 | 1.06E-35 | −0.380 | 4.09E-11 | 3.76E-06 | 0.013 | 11 |
| mQTL | LBC-BSGS | blood | 3 | XCR1 | rs13069742 | 1.81E-31 | 8.71E-12 | −0.842 | 3.81E-09 | 3.50E-04 | 0.413 | 12 |
| mQTL | LBC-BSGS | blood | 3 | NA | rs71325091 | 1.55E-21 | 1.72E-10 | −0.888 | 1.13E-07 | 0.010 | 0.055 | 19 |
Chr, chromosome; NSNP, number of SNPs.