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. 2021 Sep 7;8:654867. doi: 10.3389/fmed.2021.654867

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Copyright © 2021 Yu, Zheng, Lu, Deng, Xu, Guo, Wu, Wang, Liu, Huang and Song.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GB1a alleviates the symptoms of DSS-induced UC in mice. (A–D) GB1a treatment ameliorated DSS-induced body weight loss (A), DAI scores raising (B), colon shortening (C,D). (E,F) GB1a attenuates colonic pathological damage in UC mice (E) and decreased the histological scores of the colon tissues (F). (G) GB1a intervention significantly reduced the serum MPO activity in UC mice. Data are presented as means ± SD (n = 7/group). *p < 0.05, **p < 0.01, and ***p < 0.001 vs. the DSS-incubated group.