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. 2021 Sep 7;8:654867. doi: 10.3389/fmed.2021.654867

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Copyright © 2021 Yu, Zheng, Lu, Deng, Xu, Guo, Wu, Wang, Liu, Huang and Song.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The inhibitory effects of GB1a are dependent on the NF-κB signaling pathway in UC mice. (A) Treatment with GB1a down-regulated serum TNF-α and IL-6 levels in UC mice. (B,C) GB1a inhibited the expression of TNF-α, IL-6, CCL5, CCL20, CXCL1 in the colon tissue of UC mice. (D) Immunofluorescence analysis of NF-κBp65 (red) in the colon of mice. DAPI was used for nuclear staining (blue). (E) NF-κBp65 levels in whole and nuclear protein were analyzed by western blotting. Data are presented as means ± SD (n = 7/group). *p < 0.05, **p < 0.01, and ***p < 0.001 vs. the DSS-incubated group.