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. 2021 Sep 7;8:654867. doi: 10.3389/fmed.2021.654867

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Copyright © 2021 Yu, Zheng, Lu, Deng, Xu, Guo, Wu, Wang, Liu, Huang and Song.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of GB1a on the activation of the Nrf2 signaling pathway in UC mice. (A) GB1a administration reduced the levels of oxidants (MDA) and increased the levels of antioxidants (GSH, SOD) in the serum of UC mice. (B) GB1a treatment upregulated the expression of antioxidant genes Nrf2, HO-1, and MarfK. (C) Immunofluorescence analysis of Nrf2 (red) in the colon of mice. DAPI was used for nuclear staining (blue). (D) GB1a administration increased the expression of Nrf2 and HO-1 proteins and promoted Nrf2 translocation to the nucleus. (E) Representative images of immunohistochemical staining of Nrf2 and HO-1 in mice colon sections. Data are presented as means ± SD (n = 7/group). *p < 0.05, **p < 0.01, and ***p < 0.001 vs. the DSS-incubated group.