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. 2021 Sep 7;8:654867. doi: 10.3389/fmed.2021.654867

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Copyright © 2021 Yu, Zheng, Lu, Deng, Xu, Guo, Wu, Wang, Liu, Huang and Song.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The protective effect of GB1a on the intestinal mucosa (A) GB1a treatment upregulated the expression of genes ZO-1 and Occludin. (B) GB1a administration reduced the levels of fluorescein isothiocyanate (FITC)-dextran in the serum of UC mice and improved mucosal permeability in the colon. (C) Representative images of immunohistochemical staining of ZO-1 and Occludin and Claudin2 in mouse colon sections. (D,E) Ultrastructural morphology of the intestinal mucosal barrier. Data are presented as means ± SD (n = 7/group). *p < 0.05 and **p < 0.01. vs the DSS-incubated group.