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. 2021 Sep 7;15:726476. doi: 10.3389/fnins.2021.726476

FIGURE 3.

FIGURE 3

Electrophysiological changes in the retina of older Thy1-h[A30P]α-syn mice cannot be alleviated by L-DOPA treatment. ERG was used to measure the electrophysiological responses of different retinal cell types. (A,B) Quantification of the OPs, measured as the area under the curve (AUC), revealed larger OPs in 4- and 8-month-old α-syn mice as compared to WT controls for light stimuli with high intensity. (D,E) Quantification of pSTR response did not reveal any differences at 4 months of age, yet a shorter pSTR latency time was observed in 18-month-old transgenic mice as compared to WTs. (C,F) L-DOPA treatment did not have an overt rescue effect on observed OP (C) and pSTR (F) differences in α-syn mice. Repeated measures Two-Way ANOVA (A–C) with Bonferroni’s multiple comparisons post hoc test or unpaired t-test (D–F): *p < 0.05; **p < 0.01; and ***p < 0.001. Full ERG data is shown in Supplementary Figure 1.