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. 2021 Sep 7;8:730553. doi: 10.3389/fcvm.2021.730553

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Copyright © 2021 Hatanaka, Ito, Madokoro, Kamikokuryo, Niiyama, Yamada, Maruyama and Kakihana.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Circulating syndecan-1 is associated with multiple organ failure. (A) Relationship between serum syndecan-1 on Day 1 and SOFA score on Day 1. Spearman's rank correlation test indicated a weak but significant correlation (Spearman's rho = 0.23, P < 0.05). (B) Relationships between serum syndecan-1 on Day 1 and individual components of the SOFA score on Day 1. The intensities of the correlations are color-coded according to the Spearman's rho values. CV, cardiovascular system; CNS, central nervous system. *P < 0.05.